Objective To analyze the possibilities and limits of competency-based training in nursing.Method An integrative review of the literature on the subject was carried out, and an analysis was made of the results of a survey evaluating a nursing Stepping Stones course based on areas of competency.A dialog was then established between the review and the
Sandhoff disease is a severe neurodegenerative glycosphingolipid (GSL) lysosomal storage disorder, currently without treatment options.One therapeutic approach under investigation is substrate reduction therapy (SRT).By partially inhibiting GSL biosynthesis, the impaired rate of GSL catabolism is balanced by a slower rate of influx of GSLs into the
Abstract A breeding program with the aim of reducing the prevalence of mitral regurgitation (MR) caused by myxomatous mitral valve disease (MMVD) in Cavalier King Charles Spaniels (CKCS) is currently ongoing in Sweden.In this investigation 353 CKCS were selected as a sample of the population and 150 were examined by auscultation for heart murmurs w
Abstract Background There are now hundreds of systematic reviews on attention deficit hyperactivity disorder (ADHD) of variable quality.To help navigate this literature, we have reviewed systematic reviews on any topic on ADHD.Methods We searched MEDLINE, PubMed, PsycINFO, Cochrane Library, and Web of Science and performed quality assessment accord